Target：α-protein Kinase 1

Gene Name：ALPK1

Protein Name：Alpha-protein kinase 1

Human Gene Id：80216

Human Swiss Prot No：Q96QP1

Mouse Swiss Prot No：Q9CXB8

Immunogen：The antiserum was produced against synthesized peptide derived from human ALPK1. AA range:11-60

Specificity：α-protein Kinase 1 Polyclonal Antibody detects endogenous levels of α-protein Kinase 1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ALPK1;KIAA1527;LAK;Alpha-protein kinase 1;Chromosome 4 kinase;Lymphocyte alpha-protein kinase

Observed Band(KD)：139kD

Background： This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Function：function:Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.,similarity:Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.,similarity:Contains 1 alpha-type protein kinase domain.,tissue specificity:Highly expressed in liver.,

Subcellular Location：Cytoplasm, cytosol . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell projection, cilium . Localized at the base of primary cilia. .

Expression：Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina (PubMed:30967659).