Target:3BHS1
Fields:Steroid hormone biosynthesis;Metabolic pathways;Ovarian steroidogenesis;Aldosterone synthesis and secretion;Cortisol synthesis and secretion;Cushing syndrome
Gene Name:HSD3B1 3BH HSDB3A
Protein Name:3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (Trophoblast antigen FDO161G) [Includes: 3-beta-hydro
Human Gene Id:3283
Human Swiss Prot No:P14060
Mouse Swiss Prot No:P24815
Rat Swiss Prot No:P22071
Immunogen:Synthesized peptide derived from human protein . at AA range: 30-110
Specificity:3BHS1 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):41kD
Background: The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016],
Function:catalytic activity:A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.,catalytic activity:A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.,function:3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.,pathway:Lipid metabolism; steroid biosynthesis.,similarity:Belongs to the 3-beta-HSD family.,tissue specificity:Placenta and skin. Predominantly expressed in mammary gland tissue.,
Subcellular Location:Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Expression:Placenta and skin (PubMed:1401999). Predominantly expressed in mammary gland tissue.