Target:AMPD2
Fields:Purine metabolism;Metabolic pathways;Nucleotide metabolism
Gene Name:AMPD2
Protein Name:AMP deaminase 2
Human Gene Id:271
Human Swiss Prot No:Q01433
Mouse Gene Id:109674
Mouse Swiss Prot No:Q9DBT5
Rat Gene Id:362015
Rat Swiss Prot No:Q02356
Immunogen:The antiserum was produced against synthesized peptide derived from human AMPD2. AA range:131-180
Specificity:AMPD2 Polyclonal Antibody detects endogenous levels of AMPD2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:AMPD2;AMP deaminase 2;AMP deaminase isoform L
Observed Band(KD):100kD
Background: The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
Function:catalytic activity:AMP + H(2)O = IMP + NH(3).,function:AMP deaminase plays a critical role in energy metabolism.,pathway:Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.,similarity:Belongs to the adenosine and AMP deaminases family.,subunit:Homotetramer.,tissue specificity:Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.,
Subcellular Location:cytosol,
Expression:Highly expressed in cerebellum.