Target：IL-21

Fields：Cytokine-cytokine receptor interaction;JAK-STAT signaling pathway;Th17 cell differentiation;Inflammatory bowel disease

Gene Name：IL21

Protein Name：Interleukin-21

Human Gene Id：59067

Human Swiss Prot No：Q9HBE4

Mouse Gene Id：60505

Mouse Swiss Prot No：Q9ES17

Immunogen：The antiserum was produced against synthesized peptide derived from human IL21. AA range:91-140

Specificity：IL-21 Polyclonal Antibody detects endogenous levels of IL-21 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL21;Interleukin-21;IL-21;Za11

Observed Band(KD)：18kD

Background： This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

Function：function:Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.,similarity:Belongs to the IL-15/IL-21 family.,tissue specificity:Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.,

Subcellular Location：Secreted .

Expression：Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.