Target:IL18
Fields:Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Legionellosis;Yersinia infection;African trypanosomiasis;Malaria;Tuberculosis;Influenza A;Inflammatory bowel disease;Rheumatoid arthritis;Lipid and atherosclerosis
Gene Name:IL18 IGIF IL1F4
Protein Name:Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
Human Gene Id:3606
Human Swiss Prot No:Q14116
Mouse Swiss Prot No:P70380
Rat Swiss Prot No:P97636
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:IL18 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):21kD
Background: The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011],
Function:function:Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,
Subcellular Location:Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
Expression: Liver,Peripheral blood,Urinary bladder,