Target:IL-13Rα2
Fields:Cytokine-cytokine receptor interaction;JAK-STAT signaling pathway
Gene Name:IL13RA2
Protein Name:Interleukin-13 receptor subunit alpha-2
Human Gene Id:3598
Human Swiss Prot No:Q14627
Mouse Swiss Prot No:O88786
Immunogen:The antiserum was produced against synthesized peptide derived from human IL13RA2. AA range:315-364
Specificity:IL-13Rα2 Polyclonal Antibody detects endogenous levels of IL-13Rα2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:IL13RA2;IL13R;Interleukin-13 receptor subunit alpha-2;IL-13 receptor subunit alpha-2;IL-13R subunit alpha-2;IL-13R-alpha-2;IL-13RA2;Interleukin-13-binding protein;CD antigen CD213a2
Observed Band(KD):50kD
Background: The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008],
Function:domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Binds as a monomer with high affinity to interleukin 13 (IL13), but not to IL4.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,similarity:Contains 1 fibronectin type-III domain.,
Subcellular Location:Membrane; Single-pass type I membrane protein.
Expression: Brain,Lung,Prostate,Renal cell carcinoma,Testis,