Target：IL-11Rα

Fields：Cytokine-cytokine receptor interaction;JAK-STAT signaling pathway;Hematopoietic cell lineage

Gene Name：IL11RA

Protein Name：Interleukin-11 receptor subunit alpha

Human Gene Id：3590

Human Swiss Prot No：Q14626

Mouse Swiss Prot No：Q64385

Immunogen：Synthesized peptide derived from IL-11Rα . at AA range: 300-380

Specificity：IL-11Rα Polyclonal Antibody detects endogenous levels of IL-11Rα protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL11RA;Interleukin-11 receptor subunit alpha;IL-11 receptor subunit alpha;IL-11R subunit alpha;IL-11R-alpha;IL-11RA

Observed Band(KD)：45kD

Background： Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012],

Function：disease:Increased levels of IL11R are found in prostate carcinoma.,function:Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:On ligand binding, forms a multimer complex with IL6ST/gp130.,tissue specificity:Expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. Also expressed in norm

Subcellular Location：[Interleukin-11 receptor subunit alpha]: Membrane ; Single-pass type I membrane protein .; [Soluble interleukin-11 receptor subunit alpha]: Secreted .; [Isoform HCR2]: Secreted .

Expression：Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2 (PubMed:7670098). Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.