Target：TAB182

Gene Name：TNKS1BP1

Protein Name：182 kDa tankyrase-1-binding protein

Human Gene Id：85456

Human Swiss Prot No：Q9C0C2

Mouse Gene Id：228140

Mouse Swiss Prot No：P58871

Immunogen：The antiserum was produced against synthesized peptide derived from human TNKS1BP1. AA range:1601-1650

Specificity：TAB182 Polyclonal Antibody detects endogenous levels of TAB182 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TNKS1BP1;KIAA1741;TAB182;182 kDa tankyrase-1-binding protein

Observed Band(KD)：150kD

Background：PTM:ADP-ribosylated by TNKS1 (in vitro).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.,subunit:Binds to the ANK repeat domain of TNKS1 and TNKS2.,tissue specificity:Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.,

Function：PTM:ADP-ribosylated by TNKS1 (in vitro).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.,subunit:Binds to the ANK repeat domain of TNKS1 and TNKS2.,tissue specificity:Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.,

Subcellular Location：Nucleus. Cytoplasm, cytoskeleton. Chromosome. Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.

Expression：Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.