Target：AL1A3

Fields：Retinol metabolism;Metabolic pathways

Gene Name：ALDH1A3 ALDH6

Protein Name：Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3)

Human Gene Id：220

Human Swiss Prot No：P47895

Mouse Swiss Prot No：Q9JHW9

Rat Swiss Prot No：Q8K4D8

Immunogen：Synthesized peptide derived from human protein . at AA range: 290-370

Specificity：AL1A3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：56kD

Background： This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],

Function：catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,function:Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,tissue specificity:Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.,

Subcellular Location：Cytoplasm .

Expression：Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.