Target：IGF-I

Gene Name：IGF1

Protein Name：Insulin-like growth factor I

Human Gene Id：3479

Human Swiss Prot No：P05019

Mouse Gene Id：16000

Rat Gene Id：24482

Rat Swiss Prot No：P08025

Immunogen：The antiserum was produced against synthesized peptide derived from human IGF-I. AA range:100-149

Specificity：IGF-I Polyclonal Antibody detects endogenous levels of IGF-I protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IBP1;IGF-IA;IGF1A;IGFI;insulin-like growth factor 1;insulin-like growth factor IA;mechano growth factor;MGF;somatomedin C

Molecular Weight(Da)：17-22kD

Background： The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015],

Function：disease:Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.,function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.,online information:Insulin-like growth factor 1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the insulin family.,

Subcellular Location：extracellular region,extracellular space,plasma membrane,insulin-like growth factor binding protein complex,platelet alpha granule lumen,alphav-beta3 integrin-IGF-1-IGF1R complex,insulin-like growth factor ternary complex,exocytic vesicle,

Expression： Brain,Liver,PCR rescued clones,