Target：T2R16

Fields：Taste transduction

Gene Name：TAS2R16

Protein Name：Taste receptor type 2 member 16

Human Gene Id：50833

Human Swiss Prot No：Q9NYV7

Mouse Swiss Prot No：P59529

Immunogen：The antiserum was produced against synthesized peptide derived from human TAS2R16. AA range:136-185

Specificity：T2R16 Polyclonal Antibody detects endogenous levels of T2R16 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TAS2R16;Taste receptor type 2 member 16;T2R16

Observed Band(KD)：34kD

Background： This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008],

Function：function:Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.,miscellaneous:Confers bitter perception of salicin to non-taster mice.,miscellaneous:Several bitter taste receptors are expressed in a single taste receptor cell.,polymorphism:The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [MIM:103780].,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in a subset of gustducin-positive taste receptor cells of the tongue.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Expressed in a subset of gustducin-positive taste receptor cells of the tongue. Expressed in circumvallate papillae and testis (PubMed:16720576).