Target：ID2

Fields：TGF-beta signaling pathway;Hippo signaling pathway;Signaling pathways regulating pluripotency of stem cells;Transcriptional misregulation in cancer

Gene Name：ID2 BHLHB26

Protein Name：DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2)

Human Gene Id：3398

Human Swiss Prot No：Q02363

Mouse Swiss Prot No：P41136

Rat Swiss Prot No：P41137

Immunogen：Synthesized peptide derived from human protein . at AA range: 21-70

Specificity：ID2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：14kD

Background： The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011],

Function：developmental stage:Found in most early fetal tissues but not in the corresponding mature tissues.,function:ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Heterodimer with other HLH proteins.,tissue specificity:Highly expressed in early fetal tissues, including those of the central nervous system.,

Subcellular Location：Cytoplasm . Nucleus .

Expression：Highly expressed in early fetal tissues, including those of the central nervous system.