Target：ICAM-2

Fields：Cell adhesion molecules;Natural killer cell mediated cytotoxicity

Gene Name：ICAM2

Protein Name：Intercellular adhesion molecule 2

Human Gene Id：3384

Human Swiss Prot No：P13598

Mouse Swiss Prot No：P35330

Immunogen：The antiserum was produced against synthesized peptide derived from human ICAM2. AA range:151-200

Specificity：ICAM-2 Polyclonal Antibody detects endogenous levels of ICAM-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ICAM2;Intercellular adhesion molecule 2;ICAM-2;CD antigen CD102

Observed Band(KD)：30kD

Background： The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Function：function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.,online information:ICAM-2,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,

Subcellular Location：Membrane ; Single-pass type I membrane protein . Cell projection, microvillus . Co-localizes with RDX, EZR and MSN in microvilli. .

Expression： Aorta endothelial cell,Blood,Brain,Endothelial cell,Plasma,Spleen,