Target：ADAMTS-16

Gene Name：ADAMTS16

Protein Name：A disintegrin and metalloproteinase with thrombospondin motifs 16

Human Gene Id：170690

Human Swiss Prot No：Q8TE57

Mouse Gene Id：271127

Mouse Swiss Prot No：Q69Z28

Immunogen：Synthesized peptide derived from ADAMTS-16 . at AA range: 440-520

Specificity：ADAMTS-16 Polyclonal Antibody detects endogenous levels of ADAMTS-16 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADAMTS16;KIAA2029;A disintegrin and metalloproteinase with thrombospondin motifs 16;ADAM-TS 16;ADAM-TS16;ADAMTS-16

Molecular Weight(Da)：136kD

Background： This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016],

Function：cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 6 TSP type-1 domains.,tissue specificity:Expressed in fetal lung and kidney and in adult prostate and ovary.,

Subcellular Location：Secreted, extracellular space, extracellular matrix .

Expression：Expressed in fetal lung and kidney and in adult prostate and ovary.