Target：StARD13

Gene Name：STARD13

Protein Name：StAR-related lipid transfer protein 13

Human Gene Id：90627

Human Swiss Prot No：Q9Y3M8

Mouse Gene Id：243362

Mouse Swiss Prot No：Q923Q2

Immunogen：The antiserum was produced against synthesized peptide derived from human STA13. AA range:101-150

Specificity：StARD13 Polyclonal Antibody detects endogenous levels of StARD13 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：STARD13;DLC2;GT650;StAR-related lipid transfer protein 13;46H23.2;Deleted in liver cancer 2 protein;DLC-2;Rho GTPase-activating protein;START domain-containing protein 13;StARD13

Observed Band(KD)：125kD

Background： This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],

Function：function:GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 1 START domain.,subunit:Homodimer. Interacts with TAX1BP1.,tissue specificity:Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.,

Subcellular Location：Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.

Expression：Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.