Target：HTRA1

Gene Name：HTRA1 HTRA PRSS11

Protein Name：Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)

Human Gene Id：5654

Human Swiss Prot No：Q92743

Mouse Swiss Prot No：Q9R118

Rat Swiss Prot No：Q9QZK5

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：HTRA1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：52kD

Background： This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008],

Function：disease:Variations in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7) [MIM:610149]. ARMD is the leading cause of vision loss and blindness among older individuals in the developed word. It is classified as either dry (nonneovascular) or wet (neovascular). ARMD7 is a wet form, in which new blood vessels form and break beneath the retina. This leakage causes permanent damage to surrounding retinal tissue, distorting and destroying central vision. Wet ARMD is more prevalent among Asians than Caucasians.,function:Protease that regulate the availability of IGFs by cleaving IGF-binding proteins.,similarity:Belongs to the peptidase S1B family.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 Kazal-like domain.,similarity:Contains 1 PDZ (DHR) domain.,tissue specificity:Expressed in a variety of tissues, with stro

Subcellular Location：Cell membrane . Secreted . Cytoplasm, cytosol . Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635). .

Expression：Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up-regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).