Target：SSBP1

Fields：DNA replication;Mismatch repair;Homologous recombination

Gene Name：SSBP1

Protein Name：Single-stranded DNA-binding protein mitochondrial

Human Gene Id：6742

Human Swiss Prot No：Q04837

Mouse Gene Id：381760

Mouse Swiss Prot No：Q9CYR0

Rat Gene Id：54304

Rat Swiss Prot No：P28042

Immunogen：The antiserum was produced against synthesized peptide derived from human MtSSB. AA range:99-148

Specificity：SSBP1 Polyclonal Antibody detects endogenous levels of SSBP1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SSBP1;SSBP;Single-stranded DNA-binding protein; mitochondrial;Mt-SSB;MtSSB;PWP1-interacting protein 17

Observed Band(KD)：17kD

Background： SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010],

Function：function:This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 SSB domain.,subunit:Homotetramer.,

Subcellular Location：Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .

Expression：Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level).