Target：Claudin-5

Fields：Cell adhesion molecules;Tight junction;Leukocyte transendothelial migration;Pathogenic Escherichia coli infection;Hepatitis C

Gene Name：CLDN5

Protein Name：Claudin-5

Human Gene Id：7122

Human Swiss Prot No：O00501

Mouse Gene Id：12741

Mouse Swiss Prot No：O54942

Rat Gene Id：65131

Rat Swiss Prot No：Q9JKD6

Immunogen：The antiserum was produced against synthesized peptide derived from human Claudin 5. AA range:169-218

Specificity：Claudin-5 Polyclonal Antibody detects endogenous levels of Claudin-5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CLDN5;AWAL;TMVCF;Claudin-5;Transmembrane protein deleted in VCFS;TMDVCF

Observed Band(KD)：23kD

Background： This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008],

Function：function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ.,

Subcellular Location：Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Expression： Adipose tissue,Brain,Lung,Prostate,