Target:HSP40
Fields:Protein processing in endoplasmic reticulum;Influenza A
Gene Name:DNAJB1
Protein Name:DnaJ homolog subfamily B member 1
Human Gene Id:3337
Human Swiss Prot No:P25685
Mouse Gene Id:81489
Mouse Swiss Prot No:Q9QYJ3
Immunogen:The antiserum was produced against synthesized peptide derived from human HSP40. AA range:271-320
Specificity:HSP40 Polyclonal Antibody detects endogenous levels of HSP40 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:DNAJB1;DNAJ1;HDJ1;HSPF1;DnaJ homolog subfamily B member 1;DnaJ protein homolog 1;Heat shock 40 kDa protein 1;HSP40;Heat shock protein 40;Human DnaJ protein 1;hDj-1
Observed Band(KD):45kD
Background: This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Function:function:Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.,induction:By heat shock.,similarity:Contains 1 J domain.,subcellular location:Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.,subunit:Interacts with DNAJC3.,
Subcellular Location:Cytoplasm . Nucleus . Nucleus, nucleolus . Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
Expression: Brain,Heart,Lung,Placenta,