Target：A20

Fields：NF-kappa B signaling pathway;Necroptosis;NOD-like receptor signaling pathway;IL-17 signaling pathway;TNF signaling pathway;Measles;Epstein-Barr virus infection

Gene Name：TNFAIP3

Protein Name：Tumor necrosis factor alpha-induced protein 3

Human Gene Id：7128

Human Swiss Prot No：P21580

Mouse Gene Id：21929

Mouse Swiss Prot No：Q60769

Immunogen：The antiserum was produced against synthesized peptide derived from human TNAP3. AA range:321-370

Specificity：A20 Polyclonal Antibody detects endogenous levels of A20 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TNFAIP3;OTUD7C;Tumor necrosis factor alpha-induced protein 3;TNF alpha-induced protein 3;OTU domain-containing protein 7C;Putative DNA-binding protein A20;Zinc finger protein A20

Observed Band(KD)：89kD

Background： This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012],

Function：function:Interacts with NAF1 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system and may contribute to the in vivo effects of TNF (By similarity). Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains.,induction:By TNF-alpha.,similarity:Belongs to the peptidase C64 family.,similarity:Contains 1 OTU domain.,similarity:Contains 7 A20-type zinc fingers.,subunit:Homodimer. Interacts with NAF1, TAX1BP1 and TRAF2.,

Subcellular Location：Cytoplasm. Nucleus. Lysosome.; [A20p50]: Cytoplasm.

Expression： Epithelium,Testis,Trachea,